Thermo Fisher Scientific TLR7 Recombinant Rabbit Monoclonal Antibody (JA93-11)

Applications

• Western Blot (WB): 1:500–1:1,000

Product Specifications

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.

Advantages:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to larger rabbit immune repertoire

The immunogen for MA5-32658 is Human TLR7 C-terminal aa 1036–1049 (DNHVAYSQVF KETV).

Target Information

TLR7 is a highly conserved membrane protein belonging to the Toll-like receptor (TLR) family with 27 LRR (leucine-rich) repeats and a TIR domain. It plays a fundamental role in pathogen recognition and activation of innate immunity.

Key Features:

• Activated by single-stranded RNA viruses (e.g., influenza, VSV)
• Expressed in lung, placenta, and spleen
• Functions via MyD88 and TRAF6, leading to NF-κB activation and cytokine secretion
• Recognizes pathogen-associated molecular patterns (PAMPs) to mediate immune responses

For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.

제품 이미지

(이미지 없음)