Thermo Fisher Scientific PLCG2 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Recommended positive controls: Raji
• Predicted reactivity: Mouse (93%), Rat (94%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Phosphoinositide-specific phospholipase C (PLC) plays a crucial role in receptor-mediated signal transduction through the generation of the second messengers inositol 1,4,5-triphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate.
There are many mammalian PLC isozymes, including PLC beta1, beta2, beta3, beta4, gamma1, gamma2, delta1, delta2, and PLCe.

PLC delta exists as four isoforms. PLC delta1, a calcium signal amplifier, is activated by an atypical GTP-binding protein and acts as an effector for transglutaminase II-mediated oxytocin receptor and alpha1B-adrenoreceptor signaling.
Mouse PLC delta1 is highly expressed in brain, heart, lung, and testis.
PLC delta is abnormally accumulated in autopsied brains with Alzheimer’s disease (AD), suggesting a role in AD pathology.
PLC delta2 is markedly expressed in type II intestinal metaplasia and adenocarcinoma, and its expression may serve as a marker of gastric malignant transformation.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.