Thermo Fisher Scientific GSK3B Polyclonal Antibody
GSK3B 단백질에 특이적인 Rabbit Polyclonal 항체로 Western blot, IHC, ICC/IF에 사용 가능. 인간, 생쥐, 랫트 등 다양한 종에 반응. 항원 친화 크로마토그래피로 정제된 고순도 제품. 에너지 대사 및 Wnt 신호 경로 연구에 적합.
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein fragment corresponding to amino acids 211–404 of Human GSK3 beta |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.57 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2546727 |
Product Specific Information
- Recommended positive controls: 293T, K562, Mouse brain
- Predicted reactivity: Mouse (96%), Rat (89%), Zebrafish (83%), Xenopus laevis (82%), Pig (90%), Sheep (90%), Bovine (98%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
GSK3B (Glycogen Synthase Kinase 3 Beta) is a proline-directed serine/threonine protein kinase involved in energy metabolism, neuronal cell development, and body pattern formation. It negatively regulates glucose homeostasis and plays roles in inflammation, ER-stress, mitochondrial dysfunction, and apoptosis.
GSK3B is a key component of the Wnt/β-catenin signaling pathway, inhibiting Wnt signaling by mediating β-catenin degradation. It also participates in Hedgehog, Notch, and insulin signaling pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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