Thermo Fisher Scientific GFI1B Polyclonal Antibody
Thermo Fisher Scientific의 GFI1B Polyclonal Antibody는 인간, 마우스, 랫트 시료에서 GFI1B 단백질을 검출하는 고품질 rabbit IgG 항체입니다. Western blot 및 ChIP assay에 사용 가능하며, 고순도 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용됩니다.
- 카탈로그번호
- PA549692
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ChIP assay (ChIP)
- Tested Dilution: Not determined
- Publications: 1 publication available
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence around aa.322–326 (H-R-E-S-Q) derived from Human GFI1B |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2635145 |
Product Specific Information
This antibody detects endogenous levels of total GFI1B protein.
Target Information
GFI1b (zinc finger protein GFI-1b) is a proto-oncogenic transcriptional regulator essential for erythroid and megakaryocytic lineage development. It is part of the RCOR-GFI-KDM1A-HDAC complex, which suppresses genes related to multilineage blood cell development through HDAC recruitment.
GFI1b functions as both a transcriptional repressor and activator depending on promoter and cell type context. It represses SOCS1 and SOCS3 promoter activity, thereby regulating cytokine signaling pathways. It also cooperates with GATA1 to repress target genes such as BCL2L1, influencing apoptosis in leukemic cell lines.
Mutations in GFI1B are associated with Bleeding Disorder, Platelet-Type 17 (BDPLT17).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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