Thermo Fisher Scientific TCF2 Polyclonal Antibody
TCF2(HNF1B) 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot에 최적화되어 있으며, Human, Mouse, Rat 시료에 반응. 액상 형태, 1 mg/mL 농도, PBS buffer에 50% glycerol 포함. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence around aa.252–256 (R-Q-K-N-P) derived from Human HNF-1beta (TCF-2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2635143 |
Product Specific Information
The antibody detects endogenous levels of total HNF1B protein.
Target Information
Hepatocyte Nuclear Factor 1 (HNF1, also known as Homeoprotein LFB3, Transcription factor 2, TCF2, Variant hepatic nuclear factor) belongs to the homeodomain-containing superfamily of transcription factors. It is a liver-specific factor of the homeobox-containing basic helix-turn-helix family.
The protein binds to DNA as either a homodimer or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. HNF1 has been shown to function in nephron development and regulates development of the embryonic pancreas.
Mutations in the gene result in renal cysts and diabetes syndrome, noninsulin-dependent diabetes mellitus, and expression of the gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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