Thermo Fisher Scientific LGR5 Polyclonal Antibody
LGR5 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, 인간 및 생쥐 시료에 반응합니다. Western blot에 적합하며, 고순도 친화 크로마토그래피로 정제되었습니다. PBS/glycerol 용액 형태로 -20°C 보관합니다.
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Applications
- Western Blot (WB): 1:500–1:1,000
- View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence around aa.490–494 (K-I-S-N-Q) derived from Human LGR5 (GPR49) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635144 |
Product Specific Information
This antibody detects endogenous levels of total LGR5 / GPR49 protein.
Target Information
G protein-coupled receptor GPR49 (LGR5) is expressed in brain, skeletal muscle, placenta, and spinal cord. ESTs have been isolated from human brain (amygdala), embryo, placenta, germ cell, uterus, and brain libraries.
GPCRs constitute one of the largest families of signaling molecules, sharing a seven-transmembrane helix structure and existing in active and inactive forms. Activation by ligands triggers G-protein-mediated signaling and downstream effects.
Regulatory mechanisms of GPCRs are crucial for cellular physiology and pharmacological research, leading to development of major drugs such as Zyprexa and Claritin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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