Thermo Fisher Scientific Phospho-SREBP1 (Ser439) Polyclonal Antibody
SREBP1의 Ser439 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot, IHC, ICC/IF 등 다양한 응용에 적합. Human, Mouse, Rat 반응성. PBS/glycerol buffer에 보관하며 -20°C 보관 안정성 우수.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 | – |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | – |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SREBF1 (Accession P36956), corresponding to amino acid residues around phosphorylated Ser439. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818304 |
Product Specific Information
This antibody detects endogenous levels of SREBP1 only when phosphorylated at Serine 439.
Target Information
Sterol regulatory element-binding proteins (SREBPs) are transcription factors belonging to the basic helix-loop-helix leucine zipper family of DNA-binding proteins.
Three isoforms (SREBP-1a, SREBP-1c, and SREBP-2) exist in mammalian tissues, differing in structure, regulation, and function.
SREBPs are synthesized as 120 kDa inactive precursors in the endoplasmic reticulum membrane. Upon activation, they are transported to the Golgi, where proteolytic cleavage generates mature, transcriptionally active 60–78 kDa fragments.
In liver and adipose tissues, SREBPs regulate lipid and cholesterol accumulation by inducing transcription of related genes.
SREBP-1 primarily controls triglyceride synthesis, while SREBP-2 is more closely associated with cholesterol synthesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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