Thermo Fisher Scientific Phospho-PI3K p85/p55 (Tyr458, Tyr199) Polyclonal Antibody
PI3K p85/p55 단백질의 인산화 형태(Tyr458, Tyr199)를 인식하는 Rabbit Polyclonal Antibody. Western blot 및 Immunocytochemistry에 사용 가능. 액상 형태, 농도 1 mg/mL, -20°C 보관. 인슐린 신호전달 및 세포 성장 관련 연구용.
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Thermo Fisher Scientific Phospho-PI3K p85/p55 (Tyr458, Tyr199) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | - |
Product Specifications
| Item | Description |
|---|---|
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PI3-kinase p85 alpha/gamma around the phosphorylation site of Tyr467/199 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818300 |
Target Information
Phosphoinositide 3-kinase (PI3K, phospho PI3K) binds to activated (phosphorylated) protein-Tyr kinases through its SH2 domain and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane.
Phospho PI3K is necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. During insulin stimulation, it also binds to IRS-1.
Growth factors and hormones trigger this phosphorylation event, which coordinates cell growth, cell cycle entry, cell migration, and cell survival.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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