Thermo Fisher Scientific Phospho-PI3K p85/p55 (Tyr458, Tyr199) Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

1:100-1:500

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Product Specifications

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human PI3-kinase p85 alpha/ gamma around the phosphorylation site of Tyr467/199. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PI3K p85/p55,uniProtId:O00459-1,ncbiNodeId:9606,antigenRange:467,antigenLength:728,antigenImageFileName:PA5-99367_PI3K_p85p55_O00459-1_Rabbit.svg,antigenImageFileNamePDP:PA5-99367_PI3K_p85p55_O00459-1_Rabbit_PDP.jpeg,sortOrder:1},{targetFamily:PI3K p85/p55,uniProtId:P27986-1,ncbiNodeId:9606,antigenRange:199|467,antigenLength:724,antigenImageFileName:PA5-99367_PI3K_p85p55_P27986-1_Rabbit.svg,antigenImageFileNamePDP:PA5-99367_PI3K_p85p55_P27986-1_Rabbit_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2818300

Target Information

Phosphoinositide 3-kinase (PI3K, phospho PI3K) Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Phospho PI3K is necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. During insulin stimulation, it also binds to IRS-1. Growth factors and hormones trigger this phosphorylation event, which in turn coordinates cell growth, cell cycle entry, cell migration, and cell survival.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.