Thermo Fisher Scientific ADAM17 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

A suggested positive control for this product is HeLa or Jurkat whole cell lysate.

Target Information

ADAM17 (disintegrin and metalloproteinase domain-containing protein 17) cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form.
It is responsible for the proteolytic release of soluble JAM3 from endothelial cell surfaces and several other cell-surface proteins, including:

• p75 TNF-receptor
• Interleukin receptor type II
• p55 TNF-receptor
• Transforming growth factor-alpha
• L-selectin
• Growth hormone receptor
• MUC1
• Amyloid precursor protein

ADAM17 acts as an activator of the Notch pathway by mediating cleavage of Notch and generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT).
Mutations in the ADAM17 gene can result in inflammatory skin and bowel disease, neonatal type 1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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