Thermo Fisher Scientific ADAM17 Polyclonal Antibody
ADAM17 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal 항체로, Western blot에 사용 가능. HeLa 또는 Jurkat lysate를 양성 대조로 권장. ADAM17 관련 단백질 절단 및 신호전달 연구에 적합. 연구용으로만 사용.
- 카탈로그번호
- PA112517
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues 807–823 of human TACE |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2223412 |
Product Specific Information
A suggested positive control for this product is HeLa or Jurkat whole cell lysate.
Target Information
ADAM17 (disintegrin and metalloproteinase domain-containing protein 17) cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form.
It is responsible for the proteolytic release of soluble JAM3 from endothelial cell surfaces and several other cell-surface proteins, including:
- p75 TNF-receptor
- Interleukin receptor type II
- p55 TNF-receptor
- Transforming growth factor-alpha
- L-selectin
- Growth hormone receptor
- MUC1
- Amyloid precursor protein
ADAM17 acts as an activator of the Notch pathway by mediating cleavage of Notch and generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT).
Mutations in the ADAM17 gene can result in inflammatory skin and bowel disease, neonatal type 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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