Thermo Fisher Scientific PERP Polyclonal Antibody
Thermo Fisher Scientific의 PERP 폴리클로날 항체는 인간 PERP 단백질을 인식하며 Western Blot 및 Immunocytochemistry에 적합합니다. 항원 친화 크로마토그래피로 정제된 액상 형태로 제공되며, p53 매개 세포사멸 연구에 유용합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to amino acids near the carboxy terminus of human PERP |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage, store at -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11155442 |
Product Specific Information
In Western blot applications, this antibody detects a band at approximately 21 kDa.
A suggested positive control is A431 cell lysate.
PA5-19980 can be used with blocking peptide PEP-0104.
Target Information
The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in the p53 network, including Chk2, p53R2, p53AIP1, Noxa, PIDD, PID/MTA2, MTBP, and PERP, have been identified and cloned.
PERP, also termed PIGPC1 and THW, is a plasma membrane protein. p53 binds to the promoter of PERP and transcriptionally activates the PERP gene; the translated PERP protein mediates the p53-induced apoptosis.
PERP expression causes cell death and acts as a mediator of p53-induced apoptosis. It has sequence similarity to PMP-22/gas3 and is a new member of the PMP-22/gas3 family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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