Thermo Fisher Scientific STK3 Monoclonal Antibody (OTI2D4), TrueMAB

Thermo Fisher Scientific STK3 Monoclonal Antibody (OTI2D4), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

STK3 (MST2) is a STE kinase family member that acts upstream of the MAP kinase signaling pathways. It is activated by proapoptotic stimuli such as staurosporine and FAS ligand.
STK3 functions as a stress-activated, pro-apoptotic kinase that, upon caspase cleavage, translocates to the nucleus to induce chromatin condensation and DNA fragmentation.
It is a key component of the Hippo signaling pathway, which regulates organ size and tumor suppression by limiting proliferation and promoting apoptosis.
The pathway involves a kinase cascade in which STK3/MST2 and STK4/MST1, together with SAV1, activate LATS1/2 and MOB1, leading to phosphorylation and inhibition of YAP1 and WWTR1/TAZ.
Phosphorylation of YAP1 prevents its nuclear translocation, thereby regulating genes related to cell proliferation, apoptosis, and migration.
STK3/MST2 and STK4/MST1 are essential for repressing hepatocyte proliferation, preventing activation of liver stem cells, and inhibiting tumor formation.

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.

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