Thermo Fisher Scientific STK3 Monoclonal Antibody (OTI4G10), TrueMAB
STK3(MST2) 단백질을 인식하는 마우스 단클론 항체로, Western blot과 IHC(P) 분석에 적합합니다. Lyophilized 형태로 제공되며, 재구성 후 1 mg/mL 농도로 사용 가능합니다. Hippo 신호전달 경로 연구 및 세포 사멸 관련 기전 분석에 유용합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Dog, Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4G10 |
| Immunogen | Full-length protein expressed in 293T cells transfected with human STK3 expression vector |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of about 1 mg/mL.
- For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
STK3 (MST2) is a member of the STE kinase family acting upstream of the MAP kinase signaling pathways. It is activated by pro-apoptotic stimuli such as staurosporine and FAS ligand. STK3 functions as a stress-activated, pro-apoptotic kinase that, upon caspase cleavage, translocates into the nucleus to induce chromatin condensation and DNA fragmentation.
It plays a key role in the Hippo signaling pathway, which regulates organ size and tumor suppression by restricting proliferation and promoting apoptosis. STK3/MST2 and STK4/MST1, together with SAV1, activate LATS1/2 and MOB1, which in turn phosphorylate and inactivate the YAP1 and WWTR1/TAZ oncoproteins. This phosphorylation prevents nuclear translocation of YAP1, thereby controlling genes involved in proliferation, cell death, and migration.
STK3/MST2 and STK4/MST1 are essential for repressing hepatocyte proliferation, preventing activation of adult liver stem cells, and inhibiting tumor formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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