Thermo Fisher Scientific STK3 Monoclonal Antibody (OTI4G10), TrueMAB

Applications

Product Specifications

Product Specific Information

• For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of about 1 mg/mL.
• For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

STK3 (MST2) is a member of the STE kinase family acting upstream of the MAP kinase signaling pathways. It is activated by pro-apoptotic stimuli such as staurosporine and FAS ligand. STK3 functions as a stress-activated, pro-apoptotic kinase that, upon caspase cleavage, translocates into the nucleus to induce chromatin condensation and DNA fragmentation.

It plays a key role in the Hippo signaling pathway, which regulates organ size and tumor suppression by restricting proliferation and promoting apoptosis. STK3/MST2 and STK4/MST1, together with SAV1, activate LATS1/2 and MOB1, which in turn phosphorylate and inactivate the YAP1 and WWTR1/TAZ oncoproteins. This phosphorylation prevents nuclear translocation of YAP1, thereby controlling genes involved in proliferation, cell death, and migration.

STK3/MST2 and STK4/MST1 are essential for repressing hepatocyte proliferation, preventing activation of adult liver stem cells, and inhibiting tumor formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 없음)