Thermo Fisher Scientific DLL4 Monoclonal Antibody (4A11)
Human DLL4 단백질을 인식하는 Mouse 모노클론 항체로 Western blot, Flow cytometry, ELISA에 적합합니다. 단백질 G 정제, PBS 버퍼에 0.05% sodium azide 포함. 단기 4°C, 장기 -20°C 보관. 연구용으로만 사용.
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Thermo Fisher Scientific DLL4 Monoclonal Antibody (4A11)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4A11 |
| Immunogen | Purified recombinant fragment of human DLL4 expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2538539 |
Product Specific Information
MA5-17068 targets DLL4 in FACS, indirect ELISA, and WB applications and shows reactivity with human samples.
This product is derived from clone #4A11F8 (Mouse IgG2b) and clone #4A11G2 (Mouse IgG1).
The immunogen is a purified recombinant fragment of human DLL4 expressed in E. coli.
MA5-17068 detects DLL4, which has a predicted molecular weight of approximately 74.6 kDa.
Target Information
Delta-like ligand 4 (DLL4), also known as Delta-4, is a homologue of the Drosophila delta protein and functions as a transmembrane ligand for the Notch1 receptor.
DLL4 is expressed in the vasculature and plays a critical role in vascular development. It is induced by vascular endothelial growth factor (VEGF) as a negative feedback regulator to control angiogenic sprouting and promote formation of a differentiated vascular network.
DLL4 is strongly expressed in tumor vessels of clear-cell renal tumors and bladder cancer. Inhibition of DLL4 results in increased vascular proliferation but defective maturation, leading to reduced tumor growth without apparent toxicity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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