Thermo Fisher Scientific DLL4 Monoclonal Antibody (4A11F8)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:1,000

-

ELISA (ELISA)

1:10,000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

4A11F8

Immunogen

Purified recombinant fragment of human DLL4 (amino acids: 313-439) expressed in E. Coli. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:DLL4,uniProtId:Q9NR61-1,ncbiNodeId:9606,antigenRange:313-439,antigenLength:685,antigenImageFileName:MA5-17069_DLL4_Q9NR61-1_House_mouse.svg,antigenImageFileNamePDP:MA5-17069_DLL4_Q9NR61-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

PBS

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2538540

Product Specific Information

MA5-17069 targets DLL4 in indirect ELISA, IHC and WB applications and shows reactivity with Human samples.

The MA5-17069 immunogen is purified recombinant fragment of human DLL4 (amino acids: 313-439) expressed in E. Coli.

MA5-17069 detects DLL4 which has a predicted molecular weight of approximately 74.6kDa.

Target Information

Delta-like ligand 4 (DLL4), also know as Delta-4, is a homologue of the Drosophila delta protein, and functions as a transmembrane bound ligand to the notch receptor Notch1. DLL4 is expressed in the vasculature and plays a critical role in vascular development. It is induced by vascular endothelial growth factor (VEGF), as a negative feedback regulator to regulate angiogenic sprouting and promote the formulation of a differentiated vascular network. DLL4 has been found to be strongly expressed in tumor vessels of clear-cell renal tumors and bladder cancer, and inhibition of DLL4 results in increased vascular proliferation but defective maturation. This in turn leads to a decrease in tumor growth, with no apparent toxicity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.