Thermo Fisher Scientific DLL4 Monoclonal Antibody (4A11F8)
DLL4 단백질을 표적하는 Mouse IgG1 단클론 항체로, Human 시료에 반응합니다. Western blot, IHC, ELISA에 적합하며, 고순도 Protein G 정제 및 안정적인 액상 형태로 제공됩니다. 혈관 발달 및 종양 연구에 활용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200–1:1,000 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4A11F8 |
| Immunogen | Purified recombinant fragment of human DLL4 (amino acids 313–439) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at −20°C and avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2538540 |
Product Specific Information
MA5-17069 targets DLL4 in indirect ELISA, IHC, and WB applications and shows reactivity with human samples.
The immunogen is a purified recombinant fragment of human DLL4 (amino acids 313–439) expressed in E. coli.
MA5-17069 detects DLL4 with a predicted molecular weight of approximately 74.6 kDa.
Target Information
Delta-like ligand 4 (DLL4), also known as Delta-4, is a homologue of the Drosophila delta protein and functions as a transmembrane ligand to the Notch receptor (Notch1). DLL4 is expressed in the vasculature and plays a critical role in vascular development. It is induced by VEGF and acts as a negative feedback regulator to control angiogenic sprouting and promote formation of a differentiated vascular network.
DLL4 is strongly expressed in tumor vessels of clear-cell renal tumors and bladder cancer. Inhibition of DLL4 increases vascular proliferation but impairs maturation, resulting in decreased tumor growth without apparent toxicity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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