Thermo Fisher Scientific FAS Monoclonal Antibody (4F8H6)
인간 FAS 단백질을 인식하는 Mouse IgG1 모노클로날 항체. WB, ICC/IF, Flow Cytometry, ELISA 등 다양한 응용에 사용 가능. 고순도 Protein G 정제, 1 mg/mL 농도의 액상 형태. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | - |
| Immunocytochemistry (ICC/IF) | 1:200–1:1,000 | - |
| Flow Cytometry (Flow) | 1:200–1:400 | 1 publication |
| ELISA | 1:10,000 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4F8H6 |
| Immunogen | Purified recombinant fragment of human FAS expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2538544 |
Product Specific Information
MA5-17073 targets FAS in indirect ELISA, FACS, ICC, IF, and WB applications and shows reactivity with human samples.
The immunogen is a purified recombinant fragment of human FAS expressed in E. coli.
MA5-17073 detects FAS with a predicted molecular weight of approximately 37.7 kDa.
Target Information
FAS (Fas, CD95, APO-1) is a 46 kDa transmembrane glycoprotein functioning as a cell death receptor in the TNFR superfamily. A soluble form (~26 kDa) also exists.
Stimulation of FAS triggers aggregation of FAS-associated death domains (FADD), formation of the death-inducing signaling complex (DISC), and activation of caspases, leading to apoptosis.
FAS can activate NF-κB, MAPK3/ERK1, MAPK8/JNK, and is involved in proliferative signaling in fibroblasts and T cells.
Multiple alternatively spliced transcript variants encode distinct isoforms, with some lacking the transmembrane domain and negatively regulating apoptosis.
The Fas/Fas ligand system is implicated in diseases such as AIDS, hepatitis, and cancer, and plays a key role in antiviral immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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