Thermo Fisher Scientific FAS Monoclonal Antibody (4F8H6)

Applications and Tested Dilution

Product Specifications

Product Specific Information

MA5-17073 targets FAS in indirect ELISA, FACS, ICC, IF, and WB applications and shows reactivity with human samples.
The immunogen is a purified recombinant fragment of human FAS expressed in E. coli.
MA5-17073 detects FAS with a predicted molecular weight of approximately 37.7 kDa.

Target Information

FAS (Fas, CD95, APO-1) is a 46 kDa transmembrane glycoprotein functioning as a cell death receptor in the TNFR superfamily. A soluble form (~26 kDa) also exists.
Stimulation of FAS triggers aggregation of FAS-associated death domains (FADD), formation of the death-inducing signaling complex (DISC), and activation of caspases, leading to apoptosis.
FAS can activate NF-κB, MAPK3/ERK1, MAPK8/JNK, and is involved in proliferative signaling in fibroblasts and T cells.
Multiple alternatively spliced transcript variants encode distinct isoforms, with some lacking the transmembrane domain and negatively regulating apoptosis.
The Fas/Fas ligand system is implicated in diseases such as AIDS, hepatitis, and cancer, and plays a key role in antiviral immune responses.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.