Thermo Fisher Scientific KAT13C/NCOA2 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

SRC2 (steroid receptor coactivator 2), also known as nuclear receptor coactivator 2 (NCOA2 or TIF2), functions as a coactivator for nuclear hormone receptors. These receptors act as conditional transcription factors that regulate gene expression involved in cell growth, development, and homeostasis. Members of this receptor family, including steroid and class II nuclear receptors, share three structural domains:

• N-terminal transcriptional activation domain
• Central DNA-binding domain
• C-terminal hormone-binding domain

In the absence of hormone, steroid receptors remain inactive in complexes with heat-shock proteins. Hormone binding induces conformational changes that release the receptors, allowing them to bind DNA enhancer elements as homodimers and activate gene transcription with the help of coactivator proteins such as SRC2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.