Thermo Fisher Scientific KAT13C/NCOA2 Polyclonal Antibody
KAT13C/NCOA2 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, ELISA, IP 등에 적합합니다. Human, Mouse, Rat 시료에 반응하며, 합성 펩타이드 면역원으로 제작되었습니다. 액상 형태로 보관은 -20°C에서 권장됩니다.
- 카탈로그번호
- NUCR2-101AP
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid 1375–1425 on rat NuCR2/GRIP-1/SRC-2 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
SRC2 (steroid receptor coactivator 2), also known as nuclear receptor coactivator 2 (NCOA2 or TIF2), functions as a coactivator for nuclear hormone receptors. These receptors act as conditional transcription factors that regulate gene expression involved in cell growth, development, and homeostasis. Members of this receptor family, including steroid and class II nuclear receptors, share three structural domains:
- N-terminal transcriptional activation domain
- Central DNA-binding domain
- C-terminal hormone-binding domain
In the absence of hormone, steroid receptors remain inactive in complexes with heat-shock proteins. Hormone binding induces conformational changes that release the receptors, allowing them to bind DNA enhancer elements as homodimers and activate gene transcription with the help of coactivator proteins such as SRC2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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