Thermo Fisher Scientific TAB182 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: 2–5 µg/mg lysate

Product Specifications

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Target Information

TAB182 (tankyrase 1-binding protein of 182 kDa) was identified in a two-hybrid screen in search of tankyrase 1-interacting proteins. Tankyrase 1 is a poly (ADP-ribose) polymerase (PARP) that ribosylates the negative regulator of telomere length, TRF1 (telomere-repeat binding factor). Ribosylation of TRF1 has been shown to result in inhibition of TRF1 binding and induction of telomere elongation. TAB182 and TRF1 bind multiple discrete and overlapping sites of the tankyrase 1 ankyrin domain, suggesting that TAB182 may act as a scaffold to mediate higher-order protein complex formation at telomeres. TAB182 has also been suggested to serve a role in the cytoplasm, localizing to the cytoplasmic cortical actin network.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.