Thermo Fisher Scientific TAB182 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human TAB182 protein. Validated for Western blot and immunoprecipitation. Suitable for research use in studying tankyrase 1 interactions and telomere regulation. Supplied as a liquid, unconjugated form, stored at ...
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 200 and 250 of Human tankyrase 1-binding protein of 182 kDa |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
TAB182 (tankyrase 1-binding protein of 182 kDa) was identified in a two-hybrid screen in search of tankyrase 1-interacting proteins. Tankyrase 1 is a poly (ADP-ribose) polymerase (PARP) that ribosylates the negative regulator of telomere length, TRF1 (telomere-repeat binding factor). Ribosylation of TRF1 has been shown to result in inhibition of TRF1 binding and induction of telomere elongation. TAB182 and TRF1 bind multiple discrete and overlapping sites of the tankyrase 1 ankyrin domain, suggesting that TAB182 may act as a scaffold to mediate higher-order protein complex formation at telomeres. TAB182 has also been suggested to serve a role in the cytoplasm, localizing to the cytoplasmic cortical actin network.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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