Thermo Fisher Scientific TAB182 Polyclonal Antibody
TAB182 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 Immunoprecipitation에 적합하며, 항원 친화 크로마토그래피로 정제. 인간 반응성, 액상 형태, 4°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 200 and 250 of Human tankyrase 1-binding protein of 182 kDa |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
TAB182 (tankyrase 1-binding protein of 182 kDa) was identified through a two-hybrid screen seeking tankyrase 1-interacting proteins.
Tankyrase 1 is a poly (ADP-ribose) polymerase (PARP) that ribosylates TRF1, a negative regulator of telomere length. Ribosylation inhibits TRF1 binding and promotes telomere elongation.
TAB182 and TRF1 bind multiple discrete and overlapping sites of the tankyrase 1 ankyrin domain, suggesting TAB182 acts as a scaffold for higher-order protein complex formation at telomeres.
TAB182 also localizes to the cytoplasmic cortical actin network, indicating potential cytoplasmic roles.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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