Thermo Fisher Scientific Silencer Select Human Cell Surface siRNA Library

Invitrogen™ Silencer™ Select Human Cell Surface siRNA Library

Cell surface receptors are specialized integral membrane proteins that participate in communication between the cell and its surroundings. Extracellular signaling molecules—such as hormones, neurotransmitters, cytokines, growth factors, and cell recognition molecules—bind to these receptors, triggering functional changes within the cell.

The Silencer™ Select Human Cell Surface siRNA Library contains 2,382 Ambion™ Silencer Select siRNAs targeting 794 human genes. This library of highly potent, chemically modified siRNAs was designed using the latest genome databases, including NCBI RefSeq, and cross-referenced to the Gene Ontology Consortium (GO) and HUGO Gene Nomenclature Committee (HGNC) databases.

The Silencer Select siRNAs are created using Thermo Fisher Scientific’s advanced design algorithms and locked nucleic acid (LNA) chemical modifications, ensuring the efficacy, specificity, and potency required for RNAi screening of cell surface–based signaling pathways.

주요 특징

• Superior efficacy — Up to 90% reduction in off-target effects with advanced design algorithms and LNA modifications
• Highest efficiency — 100-fold more potent siRNAs for effective knockdown studies
• Dependable — Consistent gene knockdown for reliable phenotypic results
• Convenient — Arrayed format reduces data deconvolution and accelerates target validation
• Customizable — Available in multiple scales and pooled formats to fit workflow requirements

Why use the Silencer™ Select Human Cell Surface siRNA Library?

Optimized through advanced bioinformatics and proprietary chemical modifications, Silencer Select siRNAs deliver high potency and specificity to ensure successful RNAi outcomes. This pre-designed and, where available, validated siRNA library allows researchers to achieve high-quality data supported by Thermo Fisher Scientific’s performance guarantee.

High potency and performance

Ambion Silencer Select siRNAs are among the most potent available, enabling effective gene knockdown at low concentrations. This minimizes off-target effects, reduces false negatives, and maximizes library utility for additional screening and data validation.

Each siRNA in the library is supplied at 0.25 nmol, sufficient for approximately 500 transfections (at 5 nM siRNA, 100 μL transfection volume).

Flexible options for your workflow

Thermo Fisher Scientific offers a range of pre-defined or custom siRNA libraries for human, mouse, or rat genes, available in 1, 2, or 5 nmol scales or larger quantities.
For a complete gene list or technical consultation, contact your local representative or email RNAilibraries@lifetech.com.

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