Thermo Fisher Scientific TAB182 Polyclonal Antibody
TAB182 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 IP에 적합합니다. 인간 반응성, 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 제공됩니다. TBS 버퍼에 보관하며 4°C에서 안정적으로 유지됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 350 and 400 of Human tankyrase 1-binding protein of 182 kDa |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
TAB182 (tankyrase 1-binding protein of 182 kDa) was identified in a two-hybrid screen as a tankyrase 1-interacting protein.
Tankyrase 1 is a poly (ADP-ribose) polymerase (PARP) that ribosylates TRF1, a negative regulator of telomere length.
Ribosylation of TRF1 inhibits its binding and induces telomere elongation.
TAB182 and TRF1 bind multiple overlapping sites on the tankyrase 1 ankyrin domain, suggesting TAB182 acts as a scaffold for higher-order protein complex formation at telomeres.
TAB182 also localizes to the cytoplasmic cortical actin network, indicating a potential cytoplasmic role.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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