Thermo Fisher Scientific TAB182 Polyclonal Antibody
TAB182 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot 및 Immunoprecipitation에 적합. Human tankyrase 1-binding protein(182kDa) 특정 영역(aa 350-400)을 면역원으로 사용. 4°C 보관, Wet ice 배송. 연구용 전용 시약.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 350 and 400 of Human tankyrase 1-binding protein of 182 kDa |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
TAB182 (tankyrase 1-binding protein of 182 kDa) was identified in a two-hybrid screen in search of tankyrase 1-interacting proteins. Tankyrase 1 is a poly (ADP-ribose) polymerase (PARP) that ribosylates the negative regulator of telomere length, TRF1 (telomere-repeat binding factor). Ribosylation of TRF1 inhibits TRF1 binding and induces telomere elongation. TAB182 and TRF1 bind multiple discrete and overlapping sites of the tankyrase 1 ankyrin domain, suggesting TAB182 may act as a scaffold mediating higher-order protein complex formation at telomeres. TAB182 has also been found to localize to the cytoplasmic cortical actin network, indicating a possible cytoplasmic function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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