Thermo Fisher Scientific DFNA5 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.04–0.4 µg/mL

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:

VLFDDELLMV LEPVCDDLVS GLSPTVAVLG ELKPRQQQDL VAFLQLVGCS LQGGCPGPED AGSKQLFMTA YFLVSALAEM PDSAAALLGT CCKLQIIPTL CHLLRALSDD GVSDLEDPTL TPLKDTERFG IVQRLFASAD ISLERLKSSV

Target Information

DFNA5 (deafness, autosomal dominant 5), also known as ICERE-1, is a 496 amino acid protein expressed in cochlea tissue as well as in placenta, brain, heart, liver, lung, and pancreas. It exists as two alternatively spliced isoforms (short and long).
Defects in the DFNA5 gene cause non-syndromic sensorineural deafness autosomal dominant type 5 (DFNA5), a form of hearing loss due to damage in auditory structures.
The DFNA5 gene is located on human chromosome 7, which contains over 1,000 genes and represents about 5% of the human genome. Mutations in genes on chromosome 7 are associated with disorders such as Osteogenesis imperfecta, Williams-Beuren syndrome, Pendred syndrome, Lissencephaly, Citrullinemia, and Shwachman-Diamond syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.