Thermo Fisher Scientific PCSK1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.4 µg/mL

View 2 publications 2 publications

Immunohistochemistry (IHC)

-

View 1 publication 1 publication

Product Specifications

Species Reactivity

Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to residues S(111) V Q K D S A L D L F N D P M W N(127) of mouse PC1. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PCSK1,uniProtId:P63239-1,ncbiNodeId:10090,antigenRange:112-127,antigenLength:753,antigenImageFileName:PA1-057_PCSK1_P63239-1_Rabbit.svg,antigenImageFileNamePDP:PA1-057_PCSK1_P63239-1_Rabbit_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 1mg/mL BSA

Contains

0.05% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2158588

Product Specific Information

PA1-057 detects prohormone convertase 1 (PC1) from mouse pituitary extract.

PA1-057 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~80 kDa protein representing PC1 from mouse pituitary extract.

The PA1-057 immunogen is a synthetic peptide corresponding to residues S(111) V Q K D S A L D L F N D P M W N(127) of mouse PC1. This sequence is 88% and 82% conserved bovine and rat, respectively. The PA1-057 immunizing peptide (Cat. # PEP-164) is available for use in neutralization and control experiments.

Target Information

The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a type I proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. It is also known to cleave proopiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and progastrin. Mutations in this gene are thought to cause obesity. This encoded protein is associated with carcinoid tumors. The use of alternate polyadenylation sites has been found for this gene. Multiple alternatively spliced transcript variants have been described for this gene but their full length nature is not known.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.