Thermo Fisher Scientific SAP102 Polyclonal Antibody
Rat SAP102 단백질을 검출하는 Rabbit Polyclonal Antibody로 Western blot, IHC(F) 등 다양한 응용에 적합. 항원 친화 크로마토그래피로 정제된 액상 형태이며, 고순도 및 안정적 신호 제공. 신경 시냅스 단백질 연구용으로 최적화된 연구용 시약.
- 카탈로그번호
- PA1045
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 3 µg/mL | View 4 publications |
| Immunohistochemistry (Frozen) (IHC (F)) | 10 µg/mL | - |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Rat |
| Published Species | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues G(83) P V P P K P V P G K N T P K L N G(100) of rat SAP102 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2261667 |
Product Specific Information
PA1-045 detects synapse-associated protein 102 (SAP102) from rat tissues.
It has been successfully used in Western blot and immunohistochemistry procedures.
By Western blot, this antibody detects an ~102 kDa protein representing SAP102 in rat brain homogenate.
Immunohistochemical staining of SAP102 in rat hippocampus yields a pattern consistent with post-synaptic localization.
The immunogen is a synthetic peptide corresponding to residues G(83)–G(100) of rat SAP102.
PA1-045 immunizing peptide (Cat. # PEP-023) is available for use in neutralization and control experiments.
Target Information
Synapse-Associated Protein 102 (SAP102) is a plasma membrane-associated protein found in synaptic junctions.
It contains three PDZ domains, followed by SH3 and GuK domains.
SAP102 is involved in receptor and channel clustering contributing to neuronal plasticity.
It interacts with NMDA receptors and shaker-type potassium channels sharing a T/SXV motif.
Other neuronal proteins such as β1 adrenergic receptor, serotonin receptors, and sodium channel subunits may also interact with SAP102 via PDZ domains.
Neuronal nitric oxide synthase (nNOS), which lacks the T/SXV motif, can associate with SAP102 through PDZ-PDZ interaction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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