Thermo Fisher Scientific FOXP3 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This antibody is predicted to react with non-human primates based on sequence homology.

Target Information

FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, conserved across mammals and essential for immune homeostasis. It is expressed at high levels in CD25⁺ CD4⁺ regulatory T cells, low levels in CD4⁺/CD25⁻ cells, and absent in CD4⁻/CD8⁺ T cells.
FOXP3 functions as a master regulatory gene and a specific marker of regulatory T cells. Mutations in FOXP3 cause the scurfy phenotype in mice and are associated with IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome) in humans.
Transcript variants encoding different isoforms have been identified. In human breast and colon cancer cells, FOXP3 expression is regulated by p53 in response to DNA damage.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.