Thermo Fisher Scientific FOXP3 Polyclonal Antibody
FOXP3 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, Flow Cytometry 등에 적합합니다. 인간 및 마우스 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 면역 조절 관련 연구에 유용합니다.
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- PA512396
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:50 |
| Flow Cytometry (Flow) | 1:10–1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide corresponding to amino acids 283–311 of human FOXP3 (C-terminal region) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Antigen affinity chromatography, Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2104912 |
Product Specific Information
This antibody is predicted to react with non-human primates based on sequence homology.
Target Information
FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, conserved across mammals and essential for immune homeostasis. It is expressed at high levels in CD25⁺ CD4⁺ regulatory T cells, low levels in CD4⁺/CD25⁻ cells, and absent in CD4⁻/CD8⁺ T cells.
FOXP3 functions as a master regulatory gene and a specific marker of regulatory T cells. Mutations in FOXP3 cause the scurfy phenotype in mice and are associated with IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome) in humans.
Transcript variants encoding different isoforms have been identified. In human breast and colon cancer cells, FOXP3 expression is regulated by p53 in response to DNA damage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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