Thermo Fisher Scientific GADD45A Polyclonal Antibody
GADD45A 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, Flow cytometry에 사용 가능. Human 반응성 확인됨. 2 mg/mL 농도의 액상 형태로 제공되며, PBS buffer에 sodium azide 포함. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000 |
| Flow Cytometry (Flow) | 1:10–1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide corresponding to amino acids 1–30 from the N-terminal region of human GADD45A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Size-exclusion chromatography, Dialysis, Ammonium sulfate precipitation |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2108064 |
Product Specific Information
This antibody is predicted to react with bovine based on sequence homology.
Target Information
GADD45 alpha, beta, and gamma are an evolutionarily conserved family of nuclear proteins that function as stress sensors responding to physiological and environmental damage. They are required for activation of the G2/M checkpoint induced by UV radiation or alkylating agents. GADD45-induced G2/M checkpoint regulation occurs through inactivation of Cdc2-cyclin B1 kinase. GADD45 forms a complex with p21 and Cdc2, serving as a core for interaction with other cell cycle regulators.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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