Thermo Fisher Scientific Phospho-WASP (Tyr291) Polyclonal Antibody
Phospho-WASP (Tyr291) 폴리클로날 항체로 인간, 마우스, 랫트 시료에서 인산화된 WASP를 특이적으로 검출합니다. Western blot 및 IHC(P) 실험에 적합하며, 고순도 정제 및 안정적인 PBS/glycerol buffer에 보관됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human WAS (Accession P42768), corresponding to amino acid residues around phosphorylated Tyr291 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817000 |
Product Specific Information
This antibody detects endogenous levels of WASP only when phosphorylated at Tyr291.
Target Information
The Wiskott-Aldrich syndrome family of proteins share similar domain structures and are involved in transducing signals from cell surface receptors to the actin cytoskeleton. These proteins are regulated by multiple stimuli and interact with several proteins. They associate with the small GTPase Cdc42, which regulates actin filament formation, and the cytoskeletal organizing complex Arp2/3.
Wiskott-Aldrich syndrome is a rare, inherited, X-linked recessive disease characterized by immune dysregulation and microthrombocytopenia, caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein expressed exclusively in hematopoietic cells, which show signaling and cytoskeletal abnormalities in patients. A transcript variant with an alternative promoter and different 5′ UTR sequence has been described, though its full-length nature is not known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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