Thermo Fisher Scientific Phospho-WASP (Tyr291) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody detects endogenous levels of WASP only when phosphorylated at Tyr291.

Target Information

The Wiskott-Aldrich syndrome family of proteins share similar domain structures and are involved in transducing signals from cell surface receptors to the actin cytoskeleton. These proteins are regulated by multiple stimuli and interact with several proteins. They associate with the small GTPase Cdc42, which regulates actin filament formation, and the cytoskeletal organizing complex Arp2/3.

Wiskott-Aldrich syndrome is a rare, inherited, X-linked recessive disease characterized by immune dysregulation and microthrombocytopenia, caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein expressed exclusively in hematopoietic cells, which show signaling and cytoskeletal abnormalities in patients. A transcript variant with an alternative promoter and different 5′ UTR sequence has been described, though its full-length nature is not known.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.