Thermo Fisher Scientific Phospho-beta Arrestin 1 (Tyr173) Polyclonal Antibody
Phospho-beta Arrestin 1 (Tyr173) 특이적 Rabbit Polyclonal Antibody로, 인산화된 ARRB1의 내인성 수준을 검출. Western blot에 최적화(1:500–1:2,000). 액상 형태, 1 mg/mL 농도, -20°C 보관. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ARRB1 (Accession P49407), corresponding to amino acid residues around phosphorylated Tyr173 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817006 |
Product Specific Information
Antibody detects endogenous levels of ARRB1 only when phosphorylated at Tyr173.
Target Information
Beta Arrestin 1 is a member of a family of proteins widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling and mediates agonist-dependent desensitization and internalization of G-protein-coupled receptors (GPCRs, e.g., beta 2-adrenergic receptor).
After ligand binding and interaction with heterotrimeric G proteins, GPCRs are phosphorylated by G-protein receptor kinases (GRKs) on serine residues. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane. Serine 412 is then dephosphorylated and the GPCRs are internalized, leading to activation of the Ras, Raf, ERK1 and 2 signaling pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일: PA5-105578_beta_Arrestin_1_P49407-1_Rabbit.svg, PA5-105578_beta_Arrestin_1_P49407-1_Rabbit_PDP.jpeg)
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