Thermo Fisher Scientific PCNA Monoclonal Antibody (OTI4G3), TrueMAB
Human PCNA 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot 및 IHC(P) 분석에 적합합니다. 무보존제, 동결건조 형태로 제공되며, DNA 복제 및 수선 관련 연구에 활용됩니다.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific PCNA Monoclonal Antibody (OTI4G3), TrueMAB
Applications
- Western Blot (WB): 1:2,000
- Immunohistochemistry (Paraffin) (IHC (P)): 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4G3 |
| Immunogen | Full length human recombinant protein of human PCNA produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
PCNA (Proliferating Cell Nuclear Antigen) is essential for DNA replication and repair.
It interacts with CDK inhibitor p21, endonucleases Fen1 and XPG, and DNA methyltransferase MCMT.
PCNA serves as a marker for proliferating cells and tumor prognosis, being expressed during early G1 and S phases.
Located in the nucleus, PCNA forms a homotrimer that enhances leading strand synthesis during DNA replication.
Upon DNA damage, PCNA is ubiquitinated and participates in RAD6-dependent repair pathways.
Two transcript variants encoding the same protein are known, and pseudogenes are present on chromosomes 4 and X.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.