Thermo Fisher Scientific DOK3 Monoclonal Antibody (OTI2B11)
DOK3 단백질을 인식하는 Mouse IgG1 단클론 항체로, Western blot에 최적화됨. Human 및 Mouse 시료에 반응. 동결건조 형태로 제공되며, PBS + 8% trehalose 버퍼에 보관. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB)
Tested Dilution: 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2B11 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 63–317 of human DOK3 (NP_079148) produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
DOK3 proteins act as enzymatically inert adaptor or scaffolding proteins, providing docking platforms for multimolecular signaling complexes.
DOK3 negatively regulates JNK signaling in B-cells via interaction with INPP5D/SHIP1 and may modulate ABL1 function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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