Thermo Fisher Scientific GATM Monoclonal Antibody (OTI1C9)

Applications and Tested Dilution

Product Specifications

Target Information

AGAT, also known as glycine amidinotransferase (L-arginine:glycine amidinotransferase), GATM or transamidinase, is a 423 amino acid protein belonging to the amidinotransferase family.
Encoded by a gene that maps to human chromosome 15q21.1, AGAT exists as three alternatively spliced isoforms and forms a homodimer, with equilibrium between monomeric and dimeric forms favoring a monomer subunit structure.
AGAT localizes to mitochondrial inner membranes, peripheral membranes, and cytoplasm. It is expressed in placenta, fetal tissues, brain, heart, liver, lung, salivary gland, skeletal muscle, and highly in kidney.
AGAT is elevated in the myocardium during heart failure and decreased in inter-uterine growth restriction (IUGR)-associated placenta.
It catalyzes biosynthesis of guanidinoacetate, the immediate precursor of creatine, crucial for energy metabolism in muscle tissues.
Defects in AGAT are associated with arginine:glycine amidinotransferase deficiency, an autosomal recessive disorder characterized by developmental delay, mental retardation, severe speech disturbance, and creatine/phosphocreatine depletion in brain.
AGAT may be linked to embryonic and central nervous system development and may function in heart failure response by elevating local creatine synthesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.