Thermo Fisher Scientific PLIN3 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,500

Immunoprecipitation (IP)

• Tested Dilution: 2–10 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Orangutan

Target Information

TIP47 is a cargo protein involved in trafficking of the mannose-6-phosphate receptor between endosomes and the Golgi complex. Mannose 6-phosphate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and return to the Golgi complex.
The protein interacts with cytoplasmic domains of both cation-independent and cation-dependent MPRs and is required for endosome-to-Golgi transport. It also binds directly to GTPase RAB9, enhancing cargo affinity.
TIP47 has been localized in milk fat globule membranes of human and bovine origin and described as a placental protein. Increased amounts are secreted into circulation of cervix carcinoma patients, suggesting its potential role as an oncodevelopmental marker.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.