Thermo Fisher Scientific PLIN3 Polyclonal Antibody

Applications

• Western Blot (WB): 1:2,000–1:10,000
• Immunoprecipitation (IP): Assay-dependent

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Orangutan

Target Information

TIP47 (Perilipin-3) is a cargo protein involved in trafficking of the mannose-6-phosphate receptor between endosomes and the Golgi complex. Mannose 6-phosphate receptors (MPRs) deliver lysosomal hydrolases from the Golgi to endosomes and return to the Golgi complex.
This protein interacts with cytoplasmic domains of both cation-independent and cation-dependent MPRs and is required for endosome-to-Golgi transport. It also binds directly to the GTPase RAB9, increasing its affinity for cargo.

TIP47 has been localized in milk fat globule membranes of human and bovine origin and described as a placental protein. Increased amounts of TIP47 are secreted into circulation of cervix carcinoma patients, suggesting its potential as an oncodevelopmental marker.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.