Thermo Fisher Scientific PLIN3 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human Perilipin-3 (TIP47) for WB and IP applications. Provides high specificity and sensitivity. Supplied as liquid, 1 mg/mL, stored at 4°C. For research use only.
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Applications
- Western Blot (WB): 1:2,000–1:10,000
- Immunoprecipitation (IP): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1 to 50 of Human Perilipin-3 (TIP47, UniProt ID: O60664-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Orangutan
Target Information
TIP47 (Perilipin-3) is a cargo protein involved in trafficking of the mannose-6-phosphate receptor between endosomes and the Golgi complex. Mannose 6-phosphate receptors (MPRs) deliver lysosomal hydrolases from the Golgi to endosomes and return to the Golgi complex.
This protein interacts with cytoplasmic domains of both cation-independent and cation-dependent MPRs and is required for endosome-to-Golgi transport. It also binds directly to the GTPase RAB9, increasing its affinity for cargo.
TIP47 has been localized in milk fat globule membranes of human and bovine origin and described as a placental protein. Increased amounts of TIP47 are secreted into circulation of cervix carcinoma patients, suggesting its potential as an oncodevelopmental marker.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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