Thermo Fisher Scientific Phospho-Myelin Basic Protein (Marker of Oligodendrocytes and Myelin) (Thr98) Monoclonal Antibody (MBP/4276)
Oligodendrocyte 및 myelin 표지자인 MBP의 Thr98 인산화 형태를 인식하는 단클론 항체입니다. Western blot, IHC, ICC, ELISA 등 다양한 응용에 사용 가능하며, Human 시료에 반응합니다. Protein A/G 정제, PBS buffer, 무보존제 포뮬레이션입니다.
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- 4155-MSM6-P1ABX
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| ELISA | Assay-dependent |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MBP/4276 |
| Immunogen | Synthetic peptide corresponding to human MBP phosphorylated at threonine 98 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The protein encoded by the classic MBP (Myelin Basic Protein) gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. MBP-related transcripts are also expressed in bone marrow and immune system cells. These arise from the long MBP gene, also known as Golli-MBP, containing three additional exons upstream of the classic MBP exons.
Alternative splicing from Golli and MBP transcription start sites produces two sets of MBP-related transcripts and proteins:
- Golli-MBP transcripts – contain Golli-specific exons spliced to MBP exons, encoding hybrid proteins with N-terminal Golli sequence linked to MBP sequence.
- Classic MBP transcripts – contain only MBP exons, producing the well-characterized myelin basic proteins.
This conserved gene structure among species indicates that the MBP transcription unit is an integral part of the Golli transcription unit, playing a key role in regulation and function.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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