Thermo Fisher Scientific Clusterin/Apolipoprotein J (APO-J) Monoclonal Antibody (CLU/4729)
Clusterin/Apolipoprotein J (APO-J)에 특이적인 마우스 단클론 항체로, Western blot, IHC 등 다양한 분석에 사용 가능. 인간 시료 반응성. Protein A/G로 정제된 액상 항체로 4°C 보관. 세포 사멸 및 단백질 응집 연구에 적합.
- 카탈로그번호
- 1191-MSM9-Px (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Clusterin/Apolipoprotein J (APO-J) Monoclonal Antibody (CLU/4729)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2c, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CLU/4729 |
| Immunogen | Recombinant fragment (around aa150–300) of human CLU protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage conditions | 4°C, do not freeze |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
Isoform 1 functions as an extracellular chaperone that prevents aggregation of nonnative proteins and stress-induced aggregation of plasma proteins. It inhibits amyloid fibril formation by several proteins (e.g., APP, APOC2, B2M, CALCA, CSN3, SNCA, and LYZ variants) without requiring ATP. Clusterin maintains partially unfolded proteins for refolding by other chaperones (e.g., HSPA8/HSC70) but does not refold them itself.
Binding to cell surface receptors triggers internalization and degradation of the chaperone–client complex. Secreted isoform 1 protects cells against apoptosis and complement-mediated cytolysis. Intracellular isoforms interact with ubiquitin and E3 ligase complexes, promoting proteasomal degradation of target proteins such as COMMD1 and IKBKB, and modulate NF-κB transcriptional activity. Nuclear isoforms promote apoptosis, while mitochondrial isoforms inhibit BAX-dependent cytochrome c release and apoptosis. Clusterin plays a key role in regulating cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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