Thermo Fisher Scientific Clusterin/Apolipoprotein J (APO-J) Monoclonal Antibody (CLU/4729)
Clusterin/Apolipoprotein J 단백질을 인식하는 CLU/4729 모노클론 항체로, Western blot 및 면역조직화학 등 다양한 연구용 응용에 적합. 인간 반응성, 무보존제 PBS 용액 형태로 제공되며, 단백질 A/G로 정제됨. -20°C에서 보관 권장.
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Thermo Fisher Scientific Clusterin/Apolipoprotein J (APO-J) Monoclonal Antibody (CLU/4729)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2c, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CLU/4729 |
| Immunogen | Recombinant fragment (around aa150–300) of human CLU protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Isoform 1 functions as an extracellular chaperone that prevents aggregation of nonnative proteins and stress-induced aggregation of blood plasma proteins. It inhibits amyloid fibril formation by APP, APOC2, B2M, CALCA, CSN3, SNCA, and aggregation-prone LYZ variants (in vitro). Clusterin maintains partially unfolded proteins for refolding by other chaperones such as HSPA8/HSC70 but does not refold proteins itself. Binding to cell surface receptors triggers internalization and subsequent lysosomal or proteasomal degradation. Secreted isoforms protect against apoptosis and complement-mediated cytolysis, while intracellular forms promote ubiquitination and degradation of target proteins, modulating NF-kappa-B activity. Nuclear isoforms promote apoptosis; mitochondrial isoforms inhibit BAX-dependent cytochrome c release, suppressing apoptosis. Plays a role in cell proliferation regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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