Thermo Fisher Scientific hnRNP M1-M4 Polyclonal Antibody
Human, Mouse, Rat 반응성의 Rabbit Polyclonal Antibody로 hnRNP M1-M4 단백질 검출에 사용. WB, IHC, ICC/IF에 적합하며 고순도 Affinity Chromatography로 정제됨. PBS/glycerol buffer에 보존되어 안정적이며 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human HNRNPM (Accession P52272), corresponding to amino acid residues G23–A73 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818371 |
Product Specific Information
Antibody detects endogenous levels of total hnRNP M.
Target Information
Proteins that directly bind to nascent RNA polymerase II transcripts, the heterogeneous nuclear ribonucleoproteins (hnRNPs), play an important role in transcript-specific packaging and alternative splicing of pre-mRNAs.
A group of abundant hnRNPs, the M1–M4 proteins, appear as a cluster of four proteins. The M proteins are pre-mRNA binding proteins in vivo and bind avidly to poly(G) and poly(U) RNA homopolymers in vitro.
M proteins belong to the ribonucleoprotein consensus sequence family of RNA-binding proteins with similarity to a hypothetical RNA-binding protein from Saccharomyces cerevisiae.
They possess an unusual hexapeptide-repeat region rich in methionine and arginine residues (MR repeat motif), resembling a repeat in the 64 kDa subunit of cleavage stimulation factor involved in 3′-end maturation of pre-mRNAs.
Proteins immunologically related to M exist in divergent eukaryotes ranging from human to yeast.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: PA5-99438_hnRNP_M1-M4_P52272-1_Rabbit.svg, PA5-99438_hnRNP_M1-M4_P52272-1_Rabbit_PDP.jpeg)
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