Thermo Fisher Scientific CMKLR1 Polyclonal Antibody
CMKLR1 단백질을 검출하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 사용 가능하며 인간, 마우스, 랫트 반응성. 고순도 Affinity chromatography 정제, 1 mg/mL 농도, PBS/glycerol buffer 저장.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CMKLR1 (Accession Q99788), corresponding to amino acid residues F229–L279. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818374 |
Product Specific Information
Antibody detects endogenous levels of total CMKLR1.
Target Information
Chemokine-like receptor 1 (CMKLR1) is a receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK, and PI3K, leading to multifunctional effects like reduction of immune responses, enhancement of adipogenesis, and angiogenesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. CMKLR1 positively regulates adipogenesis and adipocyte metabolism and acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR, and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: PA5-99441_CMKLR1_Q99788-1_Rabbit.svg, PA5-99441_CMKLR1_Q99788-1_Rabbit_PDP.jpeg)
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