Thermo Fisher Scientific STAT1 Polyclonal Antibody
Rabbit polyclonal antibody against human STAT1, suitable for WB and IP applications. Targets residues 700–750 of STAT1. Supplied as an unconjugated liquid at 0.2 mg/mL. Recommended storage at 4°C, shipped on wet ice.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 700 and 750 of Human Signal Transducer and Activator of Transcription 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Pig
Target Information
STAT1 (Signal Transducer and Activator of Transcription 1) is a member of the STAT family of transcription factors. It can be activated by interferon-alpha, interferon-gamma, EGF, PDGF, and IL6. STAT1 regulates genes involved in cell growth, apoptosis, immune responses, and lipid metabolism. It plays a key role in cell viability in response to various stimuli and pathogen exposure.
The STAT1 gene is located on chromosome 2 and is activated by extracellular signaling polypeptides including cytokines, interferons, and growth factors. Upon phosphorylation by JAK tyrosine kinases, STAT1 enters the nucleus to regulate transcription of multiple genes.
Among the seven STAT types, STAT1, STAT3, STAT5a, and STAT5b have broad activation profiles. STAT1 is activated by ligands such as IFN-α, IFN-β, IFN-γ, IL-10, IL-6, IL-11, LIF, CNTF, G-CSF, EGF, PDGF, and CSF-1. Two alternatively spliced transcript variants encoding distinct isoforms of STAT1 have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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