Thermo Fisher Scientific Microphthalmia Transcription Factor (MITF) Recombinant Rabbit Monoclonal Antibody (MITF/2987R)
MITF 단백질을 표적하는 Thermo Fisher Scientific의 재조합 토끼 단클론 항체로, IHC, ICC, Flow Cytometry 등 다양한 응용에 적합합니다. 인간 및 개 반응성을 가지며, 단백질 A/G로 정제된 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Dog, Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | MITF/2987R |
| Immunogen | Recombinant full-length human MiTF protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Does not react with Mouse or Rat
Target Information
Mi (Microphthalmia-associated transcription factor, MITF) is a basic helix-loop-helix-leucine zipper (b-HLH-ZIP) transcription factor involved in pigmentation, mast cell, and bone development.
Mutations in Mi cause Waardenburg Syndrome type II in humans. In mice, loss of Mi leads to depigmentation in skin, eye, and inner ear, osteopetrosis, and defects in natural killer and mast cells.
There are two known isoforms differing by 66 amino acids at the N-terminus. Shorter forms (52–56 kDa) are expressed in melanocytes, while longer forms (60–70 kDa) are found in osteoclasts, B16 melanoma cells, mast cells, and heart tissue.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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