Thermo Fisher Scientific HDAC4 Monoclonal Antibody (OTI6E6), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Histone deacetylase 4 (HDAC4) deacetylates lysine residues on the N-terminal part of core histones (H2A, H2B, H3, and H4), contributing to epigenetic repression and transcriptional regulation. It plays roles in cell cycle progression, development, and muscle maturation through interaction with MEF2A, MEF2C, and MEF2D.
HDAC4 also participates in MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Mutations in the HDAC4 gene are associated with Brachydactyly-mental retardation syndrome (BDMR).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.