Thermo Fisher Scientific HDAC4 Monoclonal Antibody (OTI4A4), TrueMAB
HDAC4 단백질을 인식하는 마우스 모노클로날 항체로, Western blot에 최적화됨. 인간 유래 항원을 사용하여 제작되었으며, 동결건조 상태로 제공됨. 재구성 후 약 1 mg/mL 농도로 사용 가능. 연구용으로만 사용.
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Applications
- Western Blot (WB): 1:2,000 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4A4 |
| Immunogen | Full length human recombinant protein of human HDAC4 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, it is recommended to perform desalting again using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Histone deacetylase 4 (HDAC4) deacetylates lysine residues on core histones (H2A, H2B, H3, and H4), contributing to epigenetic repression.
It plays roles in transcriptional regulation, cell cycle progression, and developmental processes.
HDAC4 interacts with myocyte enhancer factors (MEF2A, MEF2C, MEF2D) during muscle maturation and participates in MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
Mutations in the HDAC4 gene are associated with Brachydactyly-mental retardation syndrome (BDMR).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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