Thermo Fisher Scientific Phospho-TPT1 (Ser46) Polyclonal Antibody
Phospho-TPT1 (Ser46) 폴리클로날 항체로, 인산화된 TCTP 단백질의 내인성 수준을 검출합니다. Western blot 및 IHC(파라핀) 실험에 적합하며, 인간·마우스·랫트 반응성. 고순도 정제, 액상 형태, -20°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TPT1 (Accession P13693), corresponding to amino acid residues around phosphorylated Ser46 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816143 |
Product Specific Information
Antibody detects endogenous levels of TCTP only when phosphorylated at Ser46.
Target Information
TPT1 (translationally controlled tumor protein 1) is a 23 kDa member of the TCTP family of calcium-binding proteins.
It is localized in the cytoplasm and widely expressed, serving as a transcriptional activator, calcium transporter, histamine inducer, and anti-apoptotic caspase 3 inhibitor.
TPT1 acts as a cytokine-like molecule that triggers histamine, IL-4, and IL-13 release from basophils, as well as IL-8 secretion and calcium response in eosinophils.
It plays a pivotal role in allergic diseases and, due to its wide distribution in the brain, may be involved in neurodegenerative disorders such as Alzheimer’s disease and Down syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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