Thermo Fisher Scientific Phospho-TLK1 (Ser743) Polyclonal Antibody
TLK1 단백질의 Ser743 인산화 형태를 특이적으로 인식하는 폴리클로날 항체. Western blot 및 IHC(Paraffin) 실험에 적합. 사람과 생쥐 시료 반응성. 고순도 정제, PBS/glycerol 저장용액. 연구용으로만 사용 가능.
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- PA5104670
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TLK1 (Accession Q9UKI8), corresponding to amino acid residues around phosphorylated Ser743 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2816145 |
Product Specific Information
Antibody detects endogenous levels of TLK1 only when phosphorylated at Ser743.
Target Information
TLK1 (Tousled-like kinase 1) is a nuclear serine/threonine kinase involved in chromatin assembly regulation. Originally described in Arabidopsis, TLK1 is a novel target of the DNA damage checkpoint and is rapidly inactivated upon exposure to ionizing radiation. This inactivation is mediated by the S-phase DNA damage checkpoint. TLK1 activity suppression after DNA double-strand breaks, replication blockade, or UV irradiation requires ATM, NBS, and CHK1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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