Thermo Fisher Scientific GDAP1 Polyclonal Antibody
Rabbit polyclonal antibody against GDAP1, validated for WB, IHC(P), and ELISA. Recognizes human, mouse, and rat GDAP1. Supplied as a liquid in PBS with 50% glycerol. Ideal for research on GDAP1-related neurodegenerative pathways.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Rat, Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–225 of human GDAP1 (NP_001035808.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.33 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2855171 |
Product Specific Information
Immunogen sequence:
MRLNSTGEVP VLIHGENIIC EATQIIDYLE QTFLDERTPR LMPDKESMYY PRVQHYRELL DSLPMDAYTH GCILHPELTV DSMIPAYATT RIRSQIGNTE SELKKLAEEN PDLQEAYIAK QKRLKSKLLD HDNVKYLKKI LDELEKVLDQ VETELQRRNE ETPEEGQQPW LCGESFTLAD VSLAVTLHRL KFLGFARRNW GNGKRPNLET YYERVLKRKT FNKVL
Target Information
Glutathione S-transferases (GSTs) conjugate reduced glutathione to various hydrophobic electrophiles. GDAP1 (ganglioside-induced differentiation-associated protein 1) is a GST-like protein with an extended GST domain II and a predicted transmembrane domain, distinguishing it from typical GST family members. GDAP1 may participate in signal transduction pathways for ganglioside-induced neurite differentiation and protect myelin membranes from free-radical damage. Mutations in GDAP1 cause several forms of Charcot-Marie-Tooth disease, a hereditary peripheral neuropathy characterized by reduced nerve conduction, progressive distal muscle atrophy, and absent deep tendon reflexes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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