Thermo Fisher Scientific FGFR1 Monoclonal Antibody (3C8)
인체 FGFR1 단백질을 인식하는 Mouse IgG2a 단클론 항체로, Western blot 및 ELISA에 적합합니다. 고순도 친화 크로마토그래피로 정제되었으며, PBS(pH 7.4) 용액 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3C8 |
| Immunogen | FGFR1 (AAH15035, 31–150 a.a.) 부분 재조합 단백질 (GST tag 포함, GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
AQPWGAPVEV ESFLVHPGDL LQLRCRLRDD VQSINWLRDG VQLAESNRTR ITGEEVEVQD SVPADSGLYA CVTSSPSGSD TTYFSVNVSD ALPSSEDDDD DDDSSSEEKE TDNTKPNRMP
Target Information
FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor family (FGFR1–4), which are membrane-spanning tyrosine kinases acting as high-affinity receptors for 17 fibroblast growth factors (FGF1–17).
FGF receptors are crucial in biological processes such as mesoderm induction, cell growth and migration, organ formation, and bone development.
FGFR1 undergoes alternative splicing, generating multiple variants expressed differently during embryonic and adult stages.
Mutations or chromosomal aberrations in FGFR1 are linked to disorders such as Pfeiffer syndrome, idiopathic hypogonadotropic hypogonadism (IHH), Kallmann syndrome type 2 (KAL2), osteoglophonic dysplasia (OGD), non-syndromic trigonocephaly, Jackson-Weiss syndrome, and Antley-Bixler syndrome.
Chromosomal abnormalities involving FGFR1 are also associated with stem cell myeloproliferative disorder and stem cell leukemia/lymphoma syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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