Thermo Fisher Scientific Phospho-PSD93 (Tyr340) Polyclonal Antibody
Phospho-PSD93 (Tyr340) 폴리클로날 항체로, 인간·마우스·랫트 시료에서 인산화된 PSD93 단백질 검출에 적합합니다. Western blot 및 IHC(파라핀 절편)에 사용 가능하며, 고순도 정제 및 PBS/glycerol 완충액에 저장됩니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human DLG2 (Accession Q15700), corresponding to amino acid residues around phosphorylated Tyr340. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816111 |
Product Specific Information
Antibody detects endogenous levels of PSD93 only when phosphorylated at Tyr340.
Target Information
PSD-93, also known as chapsyn-110, is a plasma membrane-associated protein found in synaptic junctions. It is uniquely expressed in Purkinje neuron cell bodies and dendrites. PSD-93 contains three PDZ domains, one SH3 domain, and a carboxyl-terminal guanylate kinase homology (GuK) domain.
PDZ-domain interactions are thought to contribute to receptor and channel clustering, influencing neuronal plasticity. PSD-93 is involved in clustering NMDA receptors and shaker-type potassium channels at the synaptic membrane.
Proteins with a threonine/serine-X-valine-COOH (T/SXV) motif may interact with PSD-93 via PDZ domains. Neuronal nitric oxide synthase (nNOS), which lacks this motif, can associate through a PDZ-PDZ interaction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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