Thermo Fisher Scientific L1CAM Monoclonal Antibody (OTI3G1), TrueMAB
인간 L1CAM 단백질을 인식하는 마우스 단클론 항체로, WB, IHC, ICC, Flow, IP 등 다양한 응용에 적합합니다. 고순도 친화 크로마토그래피 정제 제품이며, 동결건조 형태로 제공됩니다. 신경계 발달 연구 및 CRASH 관련 유전자 연구에 활용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
| Immunoprecipitation (IP) | 2–4 µg/mg |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3G1 |
| Immunogen | Full-length human recombinant L1CAM protein produced in HEK293T cells (Target family: CD171 (L1CAM), UniProt ID: P32004-1, Antigen range: 1–1257) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
L1CAM (CD171) is an axonal glycoprotein of the immunoglobulin superfamily. It contains multiple immunoglobulin-like and fibronectin type III domains, connected via a transmembrane sequence to a conserved cytoplasmic domain.
This molecule is essential for nervous system development, mediating neuronal migration and differentiation.
Mutations in L1CAM are associated with X-linked neurological disorders collectively known as CRASH syndrome (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia, and hydrocephalus).
Alternative splicing of neuron-specific exons may have functional significance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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