Thermo Fisher Scientific ID3 Monoclonal Antibody (OTI12C7), TrueMAB
ID3 단백질을 인식하는 Mouse IgG1 단일클론 항체로, WB, IHC, ICC, Flow Cytometry에 적합합니다. 인간 시료 반응성, 고순도 친화 크로마토그래피 정제, 동결건조 형태로 안정적 보관 가능. 연구용으로만 사용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI12C7 |
| Immunogen | Full length human recombinant protein of human ID3 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
ID family proteins (ID1, ID2, ID3, ID4) are basic helix-loop-helix (bHLH) proteins that dimerize with class A and B HLH proteins.
Due to the absence of the basic region, these heterodimers cannot bind DNA, thus negatively regulating DNA binding of bHLH proteins.
ID proteins inhibit muscle-specific gene expression by preventing DNA binding of E12 and Myo D.
Under differentiation conditions, ID levels decrease, allowing E12/E47 to form heterodimers with Myo D and myogenin, activating myogenic differentiation.
Expression of ID proteins is growth factor-dependent, and reduction of ID mRNA delays cell cycle reentry after growth factor stimulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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