Thermo Fisher Scientific ZC3HAV1 Polyclonal Antibody
인간 ZC3HAV1 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot과 Immunocytochemistry에 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 항체로, PBS에 0.02% sodium azide 포함. 연구용으로만 사용.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1 µg/mL | View 1 publication |
| Immunocytochemistry (ICC/IF) | 20 µg/mL | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 14 amino acid peptide near the carboxy terminus of human ZC3HAV1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11151868 |
Product Specific Information
A suggested positive control is HeLa cell lysate.
PA5-20986 can be used with blocking peptide PEP-1100.
Target Information
The zinc finger antiviral protein (ZC3HAV1) is a CCCH-type zinc finger protein that induces innate immunity against retrovirus infection by preventing accumulation of viral RNAs in the cytoplasm. It recruits the RNA processing exosome to degrade target RNAs, thereby inhibiting virus replication.
ZC3HAV1 is localized in the cytoplasm at steady state but shuttles between nucleus and cytoplasm in an XPO1-dependent manner.
ZAP is a direct target gene of IRF3 action in cellular antiviral responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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